Amyloid-β as a “Difficult Sequence” in Solid Phase Peptide Synthesis
✍ Scribed by Anna K. Tickler; Andrew B. Clippingdale; John D. Wade
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 9 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract By the early 1970s it had became apparent that the solid‐phase synthesis of ribonuclease A could not be generalized. Consequently, virtually every aspect of solid‐phase peptide synthesis (SPPS) was reexamined and improved during the decade of the 1970s. The sensitive detection and elimi
Recently we have demonstrated the advantage of solid-phase substrate pools mainly in equilibrium controlled protease-catalysed peptide syntheses. The extension of this approach to protease-catalysed acyl transfer reactions will be presented. The model reaction was systematically investigated accordi