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Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences

✍ Scribed by Coin, Irene; Beyermann, Michael; Bienert, Michael

Book ID
109946383
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
286 KB
Volume
2
Category
Article
ISSN
1750-2799

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## Abstract This article illustrates the successful and efficient solid phase assembly of hydrophobic difficult sequence peptides following both __t__‐Boc and Fmoc chemistry. The peptides were synthesized on an optimized 1,4‐butanediol dimethacrylate‐crosslinked polystyrene support (BDDMA‐PS). Four

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## Abstract After about one century of peptide chemistry, the main limitation to the accessibility of peptides and proteins via chemosynthesis is the arising of folding and aggregation phenomena. This is true not only for sequences above a critical length but also for several biologically relevant