## Abstract Evidence of __RB1__ allele loss was found in only 6% of pancreatic cancers, and we found no significant sequence abnormalities nor loss of RB protein expression in a panel of tumors and cell lines. Using reverse transcriptionβpolymerase chain reaction and Southern blot analysis, we foun
Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors
β Scribed by J. Mathivanan; K. Rohini; Mohan L. Gope; B. Anandh; Rajalakshmi Gope
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 296 KB
- Volume
- 302
- Category
- Article
- ISSN
- 0300-8177
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## Abstract ## BACKGROUND. The authors analyzed the retinoblastoma (Rb) tumorβsuppressor pathway in meningeal hemangiopericytomas (MHPCs). ## METHODS. Immunohistochemical detection of the Rb pathway proteins (Rb; E2F transcription factor 1 [E2F1]; cyclins D1, D3, and E; cyclinβdependent kinase 4