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Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors

✍ Scribed by K. Rohini; J. Mathivanan; P. D. Antony Herold Prabhu; D. K. Subbakrishna; M. L. Gope; B. A. Chandramouli; S. Sampath; B. Anandh; R. Gope


Publisher
Springer
Year
2006
Tongue
English
Weight
279 KB
Volume
300
Category
Article
ISSN
0300-8177

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Generation of loss of heterozygosity and
✍ Masamitsu Honma πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 390 KB πŸ‘ 1 views

## Abstract Loss of heterozygosity (LOH) is a critical event in the development of human cancers. LOH is thought to result from either a large deletion or recombination between homologous alleles during repair of DNA double‐strand breaks (DSBs). These types of genetic alterations produce mutations