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Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma

✍ Scribed by Claire M. Barton; Arthur B. McKie; Annette Hogg; Brita Bia; George Elia; Stewart M. A. Phillips; Shi-Fa Ding; Nicholas R. Lemoine

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
721 KB
Volume
13
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

Evidence of RB1 allele loss was found in only 6% of pancreatic cancers, and we found no significant sequence abnormalities nor loss of RB protein expression in a panel of tumors and cell lines. Using reverse transcription‐polymerase chain reaction and Southern blot analysis, we found no evidence for loss of DCC expression in pancreatic cancer cell lines, and allele loss only rarely in tumor biopsies. These findings suggest that abnormalities of RB1 and DCC are unlikely to play a major role in pancreatic carcinogenesis. © 1995 Wiley‐Liss, Inc.

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