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ALTERED RATIO OF CARBAMAZEPINE-10,11-EPOXIDE/CARBAMAZEPINE IN PLASMA OF CHILDREN: EVIDENCE OF ANTICONVULSANT DRUG INTERACTION

✍ Scribed by J. F. Schoeman; A. A. Elyas; E. M. Brett; P. T. Lascelles

Book ID
115264658
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
487 KB
Volume
26
Category
Article
ISSN
0012-1622

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Simultaneous determination by gas-liquid
Simultaneous determination by gas-liquid chromatography of carbamazepine and carbamazepine-10,11-epoxide in plasma
✍ Robin E. Chambers πŸ“‚ Article πŸ“… 1978 πŸ› Elsevier Science 🌐 English βš– 196 KB

Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in