Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in
✦ LIBER ✦
Simultaneous Determination of Carbamazepine and its Active Metabolite Carbamazepine-10,11-epoxide in Human Plasma by UPLC
✍ Scribed by Z. Ateş; T. Özden; S. Özilhan; S. Toptan
- Book ID
- 111790817
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 251 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0009-5893
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A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-l0,ll-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 a
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