Alpha-chymotrypsin-catalyzed hydrolysis of some carbonate esters
β Scribed by Atul A. Shah; Kenneth A. Connors
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 624 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
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## Previous work of Hansson and Rasmusson (1) has shown that low concentrations (lO-' M) of ascorbic acid enhance the rate of purified milk acid phosphatase catalyzed hydrolysis of phenyl phosphate by 500/o, and that higher concentrations of ascorbic acid (lo-'M) are completely inhibitory. It was
Intramolecular catalysis by a neighbouring hydroxyl group has been reported for the hydrolysis of a nmber of carboxylic esters and their derivatives (1) -( 5) and for phosphate esters (6). We now report the first example of such catalysis in the hydrolysis of carbonate esters. The p&rate profile f