## Abstract Restriction fragment length polymorphism (RFLP) analysis carried out on 45 primary neuroblastomas showed deletion of chromosome 11 sequences in 12 of 37 (32%) informative cases. Both 11p and 11q probes were informative in seven tumors; loss of all of chromosome 11, of only 11p sequences
Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma
β Scribed by Maris, John M. ;Guo, Chun ;White, Peter S. ;Hogarty, Michael D. ;Thompson, Patricia M. ;Stram, Daniel O. ;Gerbing, Robert ;Matthay, Katherine K. ;Seeger, Robert C. ;Brodeur, Garrett M.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 254 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0098-1532
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## Background: We analyzed loss of heterozygosity (loh) in 54 primary neuroblastomas (nbs) using 12 microsatellite markers on 14q32, and found that 31% (17/54) nbs showed loh. ## Procedure: The smallest region of overlap (sro) was identified between d14s62 and d14s987. ## Results: There was no
## Abstract Although it has been well documented that loss of human chromosome 11q is frequently observed in primary neuroblastomas, the smallest region of overlap (SRO) has not yet been precisely identified. Previously, we performed arrayβcomparative genomic hybridization (arrayβCGH) analysis for