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Deletion of chromosome 11 and of 14q sequences in neuroblastoma

✍ Scribed by Dr. Eri S. Srivatsan; Kuang Lin Ying; Robert C. Seeger

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 589 KB
Volume: 7
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870070106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Restriction fragment length polymorphism (RFLP) analysis carried out on 45 primary neuroblastomas showed deletion of chromosome 11 sequences in 12 of 37 (32%) informative cases. Both 11p and 11q probes were informative in seven tumors; loss of all of chromosome 11, of only 11p sequences, and of only 11q sequences was observed in 4, 1, and 2 tumors, respectively. A cytogenetic abnormality involving translocation of chromosome arm 11q to chromosome arm 1p was observed in a primary tumor. Deletion of 14q was observed in 6 of 27 (22%) informative cases. Deletion of chromosome 11 but not 14q may correlate with regional and metastatic disease. These results suggest a possible role for sequences localized to chromosome 11 and to 14q in the development and/or progression of neuroblastoma. © 1993 Wiley‐Liss, Inc.

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