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All-trans retinoic acid and short-time, high-dose cytarabine in two children with acute promyelocytic leukemia

✍ Scribed by Schmitt, Klaus; Zoubek, Andreas; Schwarz, Rudolf; Tulzer, Gerald; Koller, Elisabeth; Krieger, Otto; Lutz, Dieter; Gadner, Helmut

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 347 KB
Volume: 26
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199604)26:4<254::aid-mpo6>3.0.co;2-i

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✦ Synopsis

We report on two girls, 3 and 13 years well tolerated, although both children were old, with acute promyelocytic leukemia critically ill. They achieved a complete remis-(APL) who were successfully treated with all-sion confirmed by light microscopy, but trans retinoic acid (ATRA) 45 mg/m*/day. reverse transcriptase polymerase chain "Retinoic acid syndrome" was prevented reaction remained positive after ATRA, with short-time treatment of high dose underlining the need of further chemother-(4 X 1.5 g/m2) cytarabine. This regimen was apy.

@1996Wiley-Liss,Inc.

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