Use of all-trans retinoic acid to treat acute promyelocytic leukemia: A case with very severe features at the onset in Nicaragua
✍ Scribed by Flores, A.; Malta, A.; Pacheco, C.; Baez, F.; Ocampo, E.; Conter, V.; Masera, G.; Biondi, A.; Rovelli, A.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 278 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
We observed a child with acute promyelocytic leukemia (APL) who, at the onset, had extremely severe hemorrhagic and septic complications. According to our experience in Nicaragua, there was avery high risk of early death. The patient was successfully treated with a program that included alltrans retinoic acid (ATRA) followed by cyto- toxic chemotherapy. ATRA has two impor-tant features: it is effective in initial treatment of APL and it is inexpensive. Because of the high cost and the need for extensive supportive care, optimal myeloablative therapy used in patients with various types of acute myeloid leukemia generally cannot be given in developing countries. ATRA treatment for APL is affordable everywhere. o 1% WiIey-Liss, Inc.