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Reactive oxygen species production of neutrophils in patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid

โœ Scribed by Ohno, Eiji; Ohtsuka, Eiichi; Saburi, Yoshio; Ono, Keiji; Kikuchi, Hiroshi; Nasu, Masaru

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
39 KB
Volume
62
Category
Article
ISSN
0361-8609

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โœฆ Synopsis

We measured N-formyl-methionyl-leucyl-phenylalanine-induced reactive oxygen species production by neutrophils from three patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid using a luminol-enhanced chemiluminescence assay. The maximum level of reactive oxygen species production during all-trans retinoic acid treatment was 58.8 +/- 2.3 x 10(4) (mean +/- SEM) counted photons per seconds (cps), which was significantly higher (p<0.0001) than that of neutrophils from health volunteers (13.3 +/- 2.3 x 10(4) cps).

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