Treatment of acute promyelocytic leukemia with all-trans retinoic acid: Successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea
โ Scribed by Wen-Li Hwang; Jyh-Ping Gau; Min-Chun Chen; Ji-Hsiung Young
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 218 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0361-8609
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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,