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Aldo−Keto Reductase- and Cytochrome P450-Dependent Formation of Benzo[ a ]pyrene-Derived DNA Adducts in Human Bronchoalveolar Cells

✍ Scribed by Ruan, Qian; Gelhaus, Stacy L.; Penning, Trevor M.; Harvey, Ronald G.; Blair, Ian A.


Book ID
125507718
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
202 KB
Volume
20
Category
Article
ISSN
0893-228X

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C