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The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat

✍ Scribed by Hodek, Petr; Koblihová, Jitka; Kizek, René; Frei, Eva; Arlt, Volker M.; Stiborová, Marie


Book ID
121709040
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
459 KB
Volume
36
Category
Article
ISSN
1382-6689

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C