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P-077 Effects of cytochrome P450 1A1 and dihydrodiol dehydrogenase on the formation of benzo[a]pyrene DNA adduct in tumor tissues from lung cancer patients

โœ Scribed by Lee, H.; Chou, M.; Hsieh, W.; Shiu, Y.; Cheng, Y.; Chen, J.; Chen, C.


Book ID
118572985
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
146 KB
Volume
49
Category
Article
ISSN
0169-5002

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## Abstract Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's suscep