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Naturally Occurring Coumarins Inhibit Human Cytochromes P450 and Block Benzo[ a ]pyrene and 7,12-Dimethylbenz[ a ]anthracene DNA Adduct Formation in MCF-7 Cells

✍ Scribed by Kleiner, Heather E.; Reed, Melissa J.; DiGiovanni, John

Book ID: 121434361
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 109 KB
Volume: 16
Category: Article
ISSN: 0893-228X
DOI: 10.1021/tx025636d

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C