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Affinity maturation of antibodies requires integrity of the adult thymus

✍ Scribed by Mouhammed AbuAttieh; Diane Bender; Esther Liu; Peter Wettstein; Jeffrey L. Platt; Marilia Cascalho

Book ID
102825873
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
610 KB
Volume
42
Category
Article
ISSN
0014-2980

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✍ Jennifer J. VanAntwerp; K. Dane Wittrup πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 65 KB πŸ‘ 1 views

Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity. The present work instead examines