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The molecular and cellular basis of affinity maturation in the antibody response

✍ Scribed by G.J.V. Nossal


Book ID
119064178
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
237 KB
Volume
68
Category
Article
ISSN
0092-8674

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Thermodynamic characterization of affini
✍ Jennifer J. VanAntwerp; K. Dane Wittrup πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 65 KB πŸ‘ 1 views

Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity. The present work instead examines