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Mutational analysis of the affinity maturation of antibody 48G7

โœ Scribed by Priscilla L Yang; Peter G Schultz

Book ID
115629722
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
374 KB
Volume
294
Category
Article
ISSN
0022-2836

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Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity. The present work instead examines