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Affinity Maturation Increases the Stability and Plasticity of the Fv Domain of Anti-protein Antibodies

✍ Scribed by Juan Pablo Acierno; Bradford C. Braden; Sebastián Klinke; Fernando A. Goldbaum; Ana Cauerhff


Book ID
116663591
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
962 KB
Volume
374
Category
Article
ISSN
0022-2836

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Stability and peptide binding affinity o
✍ Wendell A. Lim; Robert O. Fox; Frederic M. Richards 📂 Article 📅 1994 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 569 KB

## Abstract We have determined the thermodynamic stability and peptide binding affinity of the carboxy‐terminal Src homology 3 (SH3) domain from the __Caenorhabditis elegans__ signal‐transduction protein Sem‐5. Despite its small size (62 residues) and lack of disulfide bonds, this domain is highly