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A study of the structural correlates of affinity maturation: Antibody affinity as a function of chemical interactions, structural plasticity and stability

✍ Scribed by Maria Pamela C. David; Jonathan James T. Asprer; Joyce Sarah A. Ibana; Gisela P. Concepcion; Eduardo A. Padlan


Book ID
116755900
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
802 KB
Volume
44
Category
Article
ISSN
0161-5890

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## Abstract The tRNA‐modifying enzyme tRNA–guanine transglycosylase (TGT) is essential for the pathogenic mechanism of __Shigella flexneri__, the causing agent of the bacterial diarrheal disease shigellosis. Herein, the synthesis of a new class of rationally designed 6‐amino‐imidazo[4,5‐__g__]quina