Advances in antisense efficacy and delivery
โ Scribed by Sudhir Agrawal; Saghir Akhtar
- Book ID
- 114152020
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 650 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0167-7799
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. While effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-viral methods of antis
Treatment of systemic disease with phosphorothioate antisense oligonucleotides (PS ASOs) has been accomplished using local or parenteral routes of administration to date. This report describes, for the first time, the effective oral delivery of a second generation oligonucleotide where significant m