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Targeted delivery of antisense oligonucleotides in cancer

โœ Scribed by F. Pastorino; D. Stuart; M. Ponzoni; T.M. Allen

Book ID
114161175
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
316 KB
Volume
74
Category
Article
ISSN
0168-3659

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Treatment of systemic disease with phosphorothioate antisense oligonucleotides (PS ASOs) has been accomplished using local or parenteral routes of administration to date. This report describes, for the first time, the effective oral delivery of a second generation oligonucleotide where significant m