✦ LIBER ✦

Polymers in gene therapy: antisense delivery systems

✍ Scribed by Zvi H. Israel; Abraham J. Domb

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 266 KB
Volume: 9
Category: Article
ISSN: 1042-7147
DOI: 10.1002/(sici)1099-1581(1998100)9:10/11<799::aid-pat807>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. While effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-viral methods of antisense delivery and also describes some of the exciting potential clinical applications of this technology.

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