Advances in Allogeneic Hematopoietic Stem Cell Transplantation

✍ Scribed by Martin Körbling (auth.), Richard K. Burt, Mary M. Brush (eds.)

• Publisher: Springer US
• Year: 1999
• Tongue: English
• Leaves: 419
• Series: Cancer Treatment and Research 101
• Edition: 1
• Category: Library

✦ Synopsis

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

✦ Table of Contents

Front Matter....Pages i-xi
Allogeneic Peripheral Blood Stem Cell Transplantation for Hematologic Diseases....Pages 1-23
Unrelated Donor Marrow Transplantation for Treatment of Childhood Hematologic Malignancies-Effect of HLA Disparity and Cell Dose....Pages 25-51
Haploidentical Transplantation....Pages 53-77
Umbilical Cord Blood Hematopoietic Stem Cell Transplantation....Pages 79-96
Non Myeloablative “Mini Transplants”....Pages 97-108
Allogeneic Hematopoietic Stem Cell Transplantation in Recipients of Cellular or Solid Organ Allografts....Pages 109-132
Allogeneic Peripheral Blood Progenitor Cell Transplantation in Solid Tumors....Pages 133-156
Hematopoietic Stem Cell Transplantation of Multiple Sclerosis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus....Pages 157-184
Advances in the Control of Cytomegalovirus Disease in Bone Marrow Transplant Patients....Pages 185-201
Adoptive Immunotherapy for EBV-Associated Malignancies....Pages 203-232
Adoptive Immunotherapy Using Donor Leukocyte Infusions to Treat Relapsed Hematologic Malignancies after Allogeneic Bone Marrow Transplantation....Pages 233-266
Clinical Use of Irradiated Donor Lymphocytes in Bone Marrow Transplantation....Pages 267-282
Dendritic Cells and their Clinical Applications....Pages 283-310
Engineering Hematopoietic Grafts Using Elutriation and Positive Cell Selection to Reduce GVHD....Pages 311-330
Monoclonal Antibody and Receptor Antagonist Therapy for GVHD....Pages 331-368
Adoptive Immunotherapy for Leukemia: Donor Lymphocytes Transduced with the Herpes Simplex Thymidine Kinase Gene....Pages 369-375
Clinical Application of Hematopoietic Stem Cell Culture and Expansion....Pages 377-388
New Cytokines and their Clinical Application....Pages 389-405
Back Matter....Pages 407-414

✦ Subjects

Oncology; Cancer Research