Hematopoietic Stem Cell Transplantation

✍ Scribed by Richard Champlin

• Publisher: Informa Healthcare
• Year: 2000
• Tongue: English
• Leaves: 609
• Edition: 1st
• Category: Library

✦ Synopsis

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation ·summarizes current understanding and development of clinical allogeneic HSC transplantation ·discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation ·considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors ·details detection of bone marrow contamination by tumor cells and removal procedures ·focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors ·explores the effects of growth factor administration and leukapheresis on PB stem cell donors ·shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use ·reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells ·employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

✦ Table of Contents

Preface......Page 4
Contents......Page 6
Contributors......Page 10
Thrombopoietin......Page 18
Preclinical Biology and Potential Clinical Utility of flt3 Ligand......Page 39
Stem Cell Factor......Page 46
Cytokine Modulation of Hematopoietic Stem Cell Phenotype......Page 62
Homing and Self-Renewal of Hematopoietic Stem Cells......Page 84
Requirements for Hematopoietic Stem Cell Engraftment and Graft Engineering......Page 101
Ins and Outs of Hematopoietic Stem Cells......Page 125
Cell Signaling by Adhesion Receptors in Normal and Leukemic Hematopoiesis......Page 139
Detection of Infrequent Cells in Blood and Bone Marrow by Flow Cytometry......Page 151
Human/Sheep Hematopoietic Chimeras......Page 167
Canine Models for Transplantation and Gene Therapy......Page 185
Murine Model of In Utero Transplantation......Page 209
CD34 Selection Using Immunomagnetic Beads......Page 237
Autologous and Allogeneic Transplantation with Blood CD34+ Cells......Page 252
Using Allogeneic Graft Engineering to Improve Long-Term Survival......Page 263
Detection and Significance of Minimal Residual Disease from Solid Tumor Malignancies in Stem Cell Autografts......Page 286
Stem Cell Isolation with Immunomagnetic Beads and Tumor Cell Contamination......Page 302
CD34 Cell Culture......Page 314
Critical Parameters Influencing the Expansion and Differentiation of Cultured Human CD34+ Cells......Page 331
Mobilization of Peripheral Blood Stem Cells from Normal Donors......Page 342
Innovative Approaches for Allogeneic Blood and Marrow Transplantation for Treatment of Hematological Malignancies......Page 370
Peripheral Blood Stem Cells for Allogeneic Transplantation......Page 391
Mechanisms of Cure of Acute Myeloid Leukemia with Allogeneic Transplantation......Page 411
Late Complications of Hematopoietic Stem Cell Transplantation......Page 421
Prevention of Acute Graft-Versus-Host Disease by Delayed or Selected Lymphocyte Add Back......Page 442
Blood Stem Cell Versus Bone Marrow Transplantation......Page 454
Autologous Peripheral Blood Stem Cell Collection and Engraftment......Page 464
Stem Cell Transplantation for Hodgkin’s Disease......Page 486
Stem Cell Transplantation for Multiple Myeloma—10 Years Later......Page 505
High-Dose Therapy for Primary and Metastatic Breast Cancer......Page 523
Gene Therapy Using Hematopoietic Stem Cells......Page 543
Gene Therapy for Human Immunodeficiency Virus Infection Using Stem Cell Transplantation......Page 559
Autografting Followed by Low-Intensity Conditioning Regimen for Allografting......Page 575
Development of Retroviral Vectors that Target Hematopoietic Stem Cells......Page 581
Index......Page 600