✍ Scribed by Chad E. Hadden
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The application of adiabatic inversion pulses to the detection of ^1^H–^15^N heteronuclear correlations is described. The pulse sequences studied were gHSQC, CRISIS‐gHSQC, gHMBC and CRISIS‐gHMBC. The poor inversion quality of rectangular 180° X pulses can lead to a loss of signal at the peripheries of the spectrum. Replacing these pulses with adiabatic sweeps significantly improves sensitivity across the potentially large ^15^N spectral window. Satellite spectrum profiles are shown to demonstrate the increase in sensitivity when employing adiabatic pulses on wide spectral widths. Additionally, the active pharmaceutical nizatidine was used as a model compound to demonstrate the improvements in the long‐range correlation data. Copyright © 2004 John Wiley & Sons, Ltd.
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