𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Long-range 1H-15N two-dimensional heteronuclear shift correlation of the alkaloid vincamine at natural abundance

✍ Scribed by Gary E. Martin

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
289 KB
Volume
34
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Long‐range ^1^H‐^15^N heteronuclear correlation pathways in the alkaloid vincamine, a structural constituent or biogenetic congener of numerous Vinca alkaloids, are reported. Correlations were observed through the use of the GHNMQC (Gradient‐enhanced Hydrogen‐Nitrogen Multiple Quantum Coherence) 2D nmr experiment at natural abundance. An unanticipated four‐bond coupling between the H15a resonance and N4 was observed in contrast to the typical two‐ and three‐bond coupling pathways. Nitrogen‐15 chemical shift comparisons are drawn between vincamine and structurally related alkaloids including ajmaline and the velbanamine portion of the semi‐synthetic alkaloid vinorelbine (Navelbine^TM^).

📜 SIMILAR VOLUMES

ChemInform Abstract: Long-Range 1H—15N H
ChemInform Abstract: Long-Range 1H—15N Heteronuclear Shift Correlation at Natural Abundance
✍ Gary E. Martin; Chad E. Hadden 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Application of accordion excitation in 1
Application of accordion excitation in 1H– 15N long-range heteronuclear shift correlation experiments at natural abundance
✍ Gary E. Martin; Chad E. Hadden 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 1 views

Accordion excitation provides the means of sampling a broad range of potential long-range heteronuclear couplings in a single experiment. Two long-range heteronuclear experiments, ACCORD-HMBC and IMPEACH-MBC, have been developed thus far that offer accordion excitation. The results obtained with the

Long-range two-dimensional 1H–15N hetero
Long-range two-dimensional 1H–15N heteronuclear shift correlation at natural abundance using GHNMQC. A study of the reverse transcriptase inhibitor delavirdine
✍ Kathleen A. Farley; Gregory S. Walker; Gary E. Martin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 350 KB 👁 2 views

Delavirdine is a novel BHAP [ bis(heteroaryl)piperazine ] RT (reverse transcriptase) inhibitor in the Ðnal stages of development for treatment of human AIDS (acquired immuno deÐciency syndrome). The assignment of the six unique nitrogen resonances in the molecule and its 5-aminoindole precursor are

Unequivocal location of sites of N-oxida
Unequivocal location of sites of N-oxidation using natural abundance long-range 1H,15N GHNMQC two-dimensional NMR
✍ Kathleen A. Farley; Phil B. Bowman; Jay C. Brumfield; Frank W. Crow; Wayne K. Du 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 1 views

A method is described for unequivocally establishing the site of N-oxidation which relies on the relatively large downÐeld shift of aliphatic nitrogen resonances following oxidation. The technique described is based on 15N at natural abundance and does not require labelling. 15N chemical shifts are

Low-level long-range 1H–15N heteronuclea
Low-level long-range 1H–15N heteronuclear shift correlation at natural abundance using a combination of 2D and selective 1D NMR methods with submicro NMR probe technology
✍ Chad E. Hadden; Gary E. Martin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB 👁 2 views

There has been burgeoning interest in the utilization of 15 N as a structural probe. A growing body of reports have appeared using gradient long-range 1 H-15 N heteronuclear shift correlation experiments at natural abundance. The majority of studies have reported data acquired using conventional 5 m