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Application of accordion excitation in 1H– 15N long-range heteronuclear shift correlation experiments at natural abundance

✍ Scribed by Gary E. Martin; Chad E. Hadden

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
99 KB
Volume
38
Category
Article
ISSN
0749-1581

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✦ Synopsis

Accordion excitation provides the means of sampling a broad range of potential long-range heteronuclear couplings in a single experiment. Two long-range heteronuclear experiments, ACCORD-HMBC and IMPEACH-MBC, have been developed thus far that offer accordion excitation. The results obtained with these experiments for 1 H-15 N heteronuclear shift correlation at natural abundance are compared. Low digitization in the second (F 1 ) frequency domain of 1 H-15 N ACCORD-HMBC potentially hampers this use of the experiment since it is prone to coupling modulation in the second frequency domain as a function of the accordion excitation delay. The constant time variable delay used in lieu of a simple accordion delay in the IMPEACH-MBC experiment circumvents homonuclear coupling modulation in F 1 , thereby improving resolution relative to the ACCORD-HMBC experiment for the same number of increments of the evolution period. Results obtained using accordion-optimized experiments are contrasted with conventional gradient HMBC (GHMBC). Accordion-optimized experiments offer a potential advantage for 1 H-15 N long-range heteronuclear shift correlation experiments due to the wide variability of long-range 1 H-15 N couplings.

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