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Adenosine dialdehyde analogs I: Regioselective synthesis of adenosine monoaldehydes

✍ Scribed by John P. Neenan; Sumittada M. Opitz; Charles L. Cooke; Michael A. Ussery; Terence C. Morrill; Linda M. Eckel

Book ID: 103983449
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 284 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00234-x

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✦ Synopsis

Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2'monoaldehyde (2). Reaction of I with N,N'-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3'-monoaldehyde ($), a new compound. Unlike 2, compound $ inhibited S-AdoHcy hydrolase and showed antiviral activity in vilro.

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