𝔖 Bobbio Scriptorium
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Synthesis of an Alanyl Adenosine Analog

✍ Scribed by Botta, Oliver; Strazewski, Peter


Book ID
111641915
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
119 KB
Volume
18
Category
Article
ISSN
0732-8311

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Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2'monoaldehyde (2). Reaction of I with N,N'-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3'-monoaldehyde ($), a new compound. Unlike 2, compound $ inhibited S-AdoHcy hydrolase and sho

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## Abstract The syntheses of the acyclic MDP analogs 27–37 is described, the carbohydrate moiety of muramic acid being replaced by acyclic amino alcohol structures. Their preparation was accomplished by hydrolytic cleavage of the cyclic, disubstituted 3‐morpholinones 2–5 and protection of the free