Acyclic Analogues of Pyrimidine Nucleosides. Synthesis of 1-(2-Hydroxyethoxy)methyl-and 1-(4-Hydroxybutyl)-5-amino Derivatives of Uracil. -Reaction of 5-aminouracil derivatives (I) with 4-bromobutyl acetate (II) or chloromethoxyethyl benzoate (V) followed by deacylation affords the title uracil der
Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil
โ Scribed by M. S. Novikov; A. A. Ozerov
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 432 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0009-3122
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Pyrimido [5,4-c]quinol-4-one (II). A\_: To a solution of 0.5 g (2o58 mmole) of the pyrimidone (V) in 5 ml of glacial acetic acid was added 0.3 ml of a 10% solution of dimethylamine in dry benzene, and the mixture was boiled for 4 h, evaporated, triturated with water, and the (II) (0.37 g, 74%) filte
## Abstract New 1,2,4โtriazine and their derived 1,2,4โtriazolo[3,4โ__b__][1,2,4]triazine derivatives were synthesized starting from 5,6โdiphenylโ1,2,4โtriazineโ3โthiol. Furthermore, the corresponding 1,2,4โtriazolo[3,4โ__b__][1,2,4]โtriazine thioglycosides and acyclic __C__โnucleoside analogs were