ChemInform Abstract: Acyclic Analogues of Pyrimidine Nucleosides. Synthesis of 1-(2-Hydroxyethoxy)methyl- and 1-(4-Hydroxybutyl)-5-amino Derivatives of Uracil.

✍ Scribed by M. S. NOVIKOV; A. A. OZEROV

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199902243

✦ Synopsis

Acyclic Analogues of Pyrimidine Nucleosides. Synthesis of 1-(2-Hydroxyethoxy)methyl-and 1-(4-Hydroxybutyl)-5-amino Derivatives of Uracil.

-Reaction of 5-aminouracil derivatives (I) with 4-bromobutyl acetate (II) or chloromethoxyethyl benzoate (V) followed by deacylation affords the title uracil derivatives (IV), (VII) and (IX) as potentially novel antivirus agents. -(NOVIKOV, M.