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Synthesis and antitumor activity of new 1,2,4-triazine and [1,2,4]triazolo[4,3-b][1,2,4]triazine derivatives and their thioglycoside and acyclic C-nucleoside analogs

✍ Scribed by Wael A. El-Sayed; Ibrahim F. Nassar; Adel A.-H. Abdel-Rahman

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 167 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.522

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✦ Synopsis

Abstract

New 1,2,4‐triazine and their derived 1,2,4‐triazolo[3,4‐b][1,2,4]triazine derivatives were synthesized starting from 5,6‐diphenyl‐1,2,4‐triazine‐3‐thiol. Furthermore, the corresponding 1,2,4‐triazolo[3,4‐b][1,2,4]‐triazine thioglycosides and acyclic C‐nucleoside analogs were synthesized. The newly synthesized compounds were evaluated for their antitumor activity and some of them showed high inhibition activities. J. Heterocyclic Chem., 2011.

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