Acute sensory ataxic neuropathy with antibodies to GD1b and GQ1b gangliosides and prompt recovery
β Scribed by Francesca Notturno; Christina M. Caporale; Antonino Uncini
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 130 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0148-639X
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A Fisher syndrome (FS) patient with antibody to tetrasyaloganglioside GQ1b (GQ1b) developed late limb weakness. Serial motor conduction velocities (MCVs) showed a marked reduction of distal compound muscle action potential (CMAP) amplitudes, worse at 2-3 weeks, followed by a dramatic increase in wee
Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incid