Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia
✍ Scribed by Dr. Michael E. Shy; Vance A. Evans; Fred D. Lublin; Robert L. Knobler; Terry Heiman-Patterson; Albert J. Tahmoush; Gareth Parry; Paul Schick; Theodora G. Deryk
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 464 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM, in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.
Shy ME, Evans VA, Lublin FD, Knobler RL, Heiman-Patterson T, Tahmoush AJ, Parry G, Schick P, DeRyk TG. Antibodies to GMI and GDlb in patients with motor neuron disease without plasma cell dyscrasia.