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Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b

✍ Scribed by Ettore Nardelli; Dr. Andreas J. Steck; Thomas Barkas; Myriam Schluep; Felix Jerusalem


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
644 KB
Volume
23
Category
Article
ISSN
0364-5134

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Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incid

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I n a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M protein reacted with the glycolipids GM1, GDlb, and asialo GM1 and, by immunoblot, with some high-molecular-weight neural-specific glycoproteins. T h e main reactive bands had an approximate molecular weight of 250

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Low affinity anti-GM 1 IgM-antibodies are part of the normal repertoire of human plasma antibodies (Mizutamari et al.: J Neuroimmunol 50:215-220, 1994), a fact that is against the pathological role proposed for them in autoimmune diseases. Here we present evidence that these low affinity IgM-antibod