Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high-molecular-weight neural-specific glycoproteins
✍ Scribed by Dr E. Nobile-Orazio; G. Legname; R. Daverio; M. Carpo; A. Giuliani; S. Sonnino; G. Scarlato
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 505 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0364-5134
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✦ Synopsis
I n a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M protein reacted with the glycolipids GM1, GDlb, and asialo GM1 and, by immunoblot, with some high-molecular-weight neural-specific glycoproteins. T h e main reactive bands had an approximate molecular weight of 250 and 400 kd, were most concentrated in the spinal cord, and were also bound by the lectin peanut agglutinin. T h e presence of the GalQ31-3)GalNAc epitope on these neuralspecific glycoproteins may help to explain the selective neurological impairment of the patient.