Chronic sensory ataxic neuropathy with polyclonal IgM reactivity to various disialosyl gangliosides

IgM M-protein with antibody activity aga

IgM M-protein with antibody activity against gangliosides with disialosyl residue in sensory neuropathy binds to sensory neurons

✍ Nobuyuki Oka; Hirofumi Kusaka; Susumu Kusunoki; Hiroshi Tsuda; Ryuji Kaji; Teruk 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB

Immunoglobulin M (IgM) M-protein in sera from patients with peripheral neuropathy frequently binds to glycoconjugates. The sulfated glucuronyl residue shared by myelin-associated glycoprotein (MAG) and sulfated glucuronyl glycolipids (SGGLs) is the epitope most frequently recognized. The IgM M-prote