IgM M-protein with antibody activity against gangliosides with disialosyl residue in sensory neuropathy binds to sensory neurons
✍ Scribed by Nobuyuki Oka; Hirofumi Kusaka; Susumu Kusunoki; Hiroshi Tsuda; Ryuji Kaji; Terukuni Imai; Ichiro Akiguchi; Jun Kimura
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 320 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
Immunoglobulin M (IgM) M-protein in sera from patients with peripheral neuropathy frequently binds to glycoconjugates. The sulfated glucuronyl residue shared by myelin-associated glycoprotein (MAG) and sulfated glucuronyl glycolipids (SGGLs) is the epitope most frequently recognized. The IgM M-protein of this type, which immunohistochemically binds to myelin of the human peripheral nerve, is specifically associated with demyelinating neuropathv. On the other hand, IgM M-protein binding to a broad spectrum of gangliosides with the disialosyl residue, such as GDlh, GDS, GTlb, and GQ,,, has been reported exclusively in cases of sensory-dominant polyneuropathy, I .3,6,10,11 The pathophysiological mechanism underlying such cases has yet to be determined. We found binding of such IgM M-protein to neurons in human dorsal root ganglia.