Activity of all-trans-retinoic acid in a case of central nervous system extramedullary relapse of acute promyelocytic leukemia
✍ Scribed by Francesca Patriarca; Carla Filì; Antonella Geromin; Alessandra Sperotto; Simonetta Prosdocimo; Renato Fanin
- Book ID
- 114423122
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 100 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0902-4441
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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A
Background. All-trans retinoic acid (ATRA) is effective in the treatment of relapsed or refractory acute promyelocytic leukemia (APL), but relapse is the rule if response is unmaintained. Methods. Seventeen patients with APL were salvaged with ATRA at a dosage of 50 mg/mz/day for 3 months or until