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Extramedullary relapse after all-trans retinoic acid treatment in acute promyelocytic leukemia – the occurrence of retinoic acid syndrome is a risk factor

✍ Scribed by Ko, B-S; Tang, J-L; Chen, Y-C; Yao, M; Wang, C-H; Shen, M-C; Tien, H-F


Book ID
110054283
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
60 KB
Volume
13
Category
Article
ISSN
0887-6924

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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,