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Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours

โœ Scribed by Segura-Aguilar, Juan; Cremades, Antonio; Llombart-Bosch, Antonio; Monsalve, Elena; Ernster, Lars; Romero, Francisco J.


Book ID
126458710
Publisher
Oxford University Press
Year
1994
Tongue
English
Weight
1022 KB
Volume
15
Category
Article
ISSN
0143-3334

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Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone E 0 9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of E