DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas
β Scribed by Walton, Michael I.; Bibby, Michael C.; Double, John A.; Plumb, Jane A.; Workman, Paul
- Book ID
- 122705173
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 575 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0959-8049
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Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone E 0 9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of E
## Abstract We have previously reported that activation of the G protein coupled calciumβsensing receptor (CaSR) by extracellular Ca^2+^ downβmodulates the expression of thymidylate synthase (TS) and survivin and promotes sensitivity to fluorouracil in human colon carcinoma cells. Here, we report f