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Active-site mutants of class B β-lactamases: substrate binding and mechanistic study

✍ Scribed by C. Prosperi-Meys; D. de Seny; G. Llabres; M. Galleni; J. Lamotte-Brasseur

Book ID
105759976
Publisher
Springer
Year
2002
Tongue
English
Weight
162 KB
Volume
59
Category
Article
ISSN
1420-682X

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✍ Xavier Raquet; Josette Lamotte-Brasseur; Fabrice Bouillenne; Jean-Marie Frère 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

Bacterial resistance to ␤-lactam antibiotics, a clinically worrying and recurrent problem, is often due to the production of ␤-lactamases, enzymes that efficiently hydrolyze the amide bond of the ␤-lactam nucleus. Imipenem and other carbapenems escape the activity of most active site serine ␤-lactam