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Interaction between class B β-lactamases and suicide substrates of active-site serine β-lactamases

✍ Scribed by Christelle Prosperi-Meys; Gabriel Llabres; Dominique de Seny; Raquel Paul Soto; Maria Hernandez Valladares; Netza Laraki; Jean-Marie Frere; Moreno Galleni


Book ID
117110288
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
82 KB
Volume
443
Category
Article
ISSN
0014-5793

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Bacterial resistance to ␤-lactam antibiotics, a clinically worrying and recurrent problem, is often due to the production of ␤-lactamases, enzymes that efficiently hydrolyze the amide bond of the ␤-lactam nucleus. Imipenem and other carbapenems escape the activity of most active site serine ␤-lactam