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Active cobalamin transport in L-1210 mouse leukemia cells

โœ Scribed by A. E. Oreshkin; N. V. Myasishcheva

Book ID
104967377
Publisher
Springer US
Year
1990
Tongue
English
Weight
302 KB
Volume
110
Category
Article
ISSN
0007-4888

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX