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Multiple DNA-dependent RNA polymerases from mouse leukemia L1210 ascites cells

โœ Scribed by Charles A. Maniglia; Robert G. Wilson


Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
563 KB
Volume
9
Category
Article
ISSN
0020-711X

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4-Quinolones cause a selective loss of m
โœ Jeffrey W. Lawrence; Sandra Darkin-Rattray; Fan Xie; Allen H. Neims; Thomas C. R ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 902 KB

The 4-quinolone antibiotics nalidixic acid and ciprofloxacin are potent inhibitors of the bacterial type II topoisomerase DNA gyrase. Treatment of mouse L1210 leukemia cells with these drugs resulted in a delayed inhibition of cell proliferation. Prior to inhibition of cell proliferation, there was